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A search of current literature suggests that no or few new active ingredients in handwashing formulation have come on the market during the last 20-plus years. In addition, nursing staffs have found that repeated use of active ingredients in handwash or hand rinse formulations can and do result in drying out their skin, which can become a source of skin irritation. Moreover, the use of powdered latex gloves together with the use of handwash formulations can result in rough, red, chapped skin, which can lead to broken skin conditions on the epidermis of caregiver hands.
Current handwashing and hand rinse products normally contain one of the following active ingredients: Chlorhexidine gluconate (known as CHG); Chloroxlyenol (known as;
PCMX); Triclosan; isopropyl alcohol, ethyl alcohol, normal-propyl alcoholand sometimes iodine. All of these active ingredients serve to inhibit transient pathogenic microorganisms to some degree. Some are better than others in the ability to inhibit opportunistic microorganisms during the initial application and in the important characteristic of persistent log reduction over time.

Striving for Balance.

Historically and in general, effectiveness in log reductions of microorganisms has been achieved at the expense of harsh formulations that degrade the hands of the caregiver. There seems to have been a trade-off between antimicrobial effectiveness and gentleness. Increasingly,
control point to prevent the spread of opportunistic and pathogenic microorganisms.6 The normal approach in managing this cross-contamination problem is with proper handwashing using a healthcare personnel handwash/ antimicrobial skin cleanser or antimicrobial hand rinse before and after each patient-handling episode.

There are many handwash product formulations with a variety of active ingredients effective in breaking the potential "chain of infection." These handwashing products are generally known as a healthcare personnel handwash or hand rinse. Most active ingredients work to inhibit, to a more or less degree, opportunistic/pathogenic microorganism flow associated with the chain of infection. Most of these active ingredients have been available to the professional healthcare community for a number of years. However, despite their efficacy, many can have degrading

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